黄志海

姓名：黄志海

性别：男

党派：中共党员

职称：副教授，硕士生导师

学历：博士研究生

联系方式：江苏省南京市江宁区东南大学九龙湖校区材料学院

                 A楼306室，211189

联系电话：17602503453

Email：huangzhihai@seu.edu.cn，huangyq79@gmail.com

Website：http://www.researcherid.com/rid/N-1409-2014；

http://seu.teacher.360eol.com/teacherBasic/preview?teacherType=&teacherId=9436

研究方向:

1. 多功能贵金属基纳米材料

2. 常温液态金属生物医学材料

3. 仿生/遗态材料及矿化

4. 生物材料与组织工程

5. 材料先进加工制备技术

生物材料与组织工程专业博士，生物医学工程专业博士后。曾入选首批国家博士后国际交流计划派出项目（2013年）；主持完成国家自然科学基金青年项目和面上项目各1项，参与国家自然科学基金项目6项。已在Journal of Materials Chemistry A、Biomaterials、Bioactive Materials、Nanoscale、Small、Autophagy等SCI期刊发表研究论文30余篇；相关成果被Chemical Reviews、ACS Nano、Biomaterials、Small、PRL、Journal of Materials Chemistry A、Nanoscale、Acta Biomaterialia、ACS Applied Materials and Interface等国际高水平期刊他引1000多次，H-index：17。现阶段研究兴趣主要在贵金属纳米酶及荧光成像、常温液态金属材料及器件、仿生/遗态材料及矿化等领域。

教育经历:

1.    2005.3～2010.6东南大学材料科学与工程学院，生物材料与组织工程专业，工学博士，导师：林萍华教授，董寅生教授

2.    2002.9～2005.3东南大学材料科学与工程学院，材料加工工程专业，工学硕士，导师：林萍华教授，董寅生教授

3.    1998.9～2002.6东南大学机械工程系，材料成型及控制工程专业（主修）/工业管理工程专业（辅修），工学学士，本科优秀毕业生，指导老师：高锦张副教授，戴挺副教授

工作经历:

Ø  2020.9～今，材料学院材料加工工程系，副系主任

Ø  2019.5～今，东南大学材料科学与工程学院，副教授

Ø  2016.12～2022.9，江苏省先进金属材料高技术研究重点实验室，秘书（兼职）

Ø  2016.12～2019.4，东南大学材料科学与工程学院，讲师

Ø  2014.5～2016.12，密西根大学化学系/东南大学生物科学与医学工程学院，博士后

Ø  2010.7～2014.5，东南大学生物科学与医学工程学院，生物医学工程专业，博士后

教学课程：

1. 工程金属材料，能源与环境学院，32学时

2. 材料工程测试技术，材料科学与工程学院，48学时

3.科技论文读写，材料科学与工程学院，32学时

4. 工业实习，材料科学与工程学院，16学时

5. 材料工业项目选型与设计，材料科学与工程学院，研究生课程，32学时

6. 功能材料导论，研究生课程，32学时

指导学生情况：

研究生课题：

1. 荧光银纳米团簇的绿色合成及其在铜、汞离子检测中的应用，周萍萍（2018级）

2. 研究方向：贵金属纳米材料的生物医学应用，题目待定，刘季锦花（2020级）

本科毕业设计：

1. 基于生物分子模板的贵金属纳米材料紫外还原合成研究，殷琦（2014级）

2. 基于微流技术连续可控合成纳米银，李嘉祎（2015级）

3. 紫外光/微波辅助合成荧光金纳米团簇，王雨婷（2016级），优秀

4. 基于球形有机基质模板仿生矿化碳酸钙的研究，方子源（2017级）

5. 纳米银涂层的抗菌导管制备研究，刘应时（2017级）

6. 蛋白配体金纳米团簇的纳米酶效应研究，伍魏东（2017级）

SRTP项目：

1. 基于微流控合成胶体纳米材料，2019，王惟钊（2016级，组长）、黄镝洁（2016级）、吴镔旭（2016级）

2. 壳聚糖/蒙脱石快速止血复合材料的制备研究，2020，伍魏东（2017级，组长）、周茂多（2017级）

3. 静电纺丝制备纳米抗菌复合材料，2020，樊雨馨（2017级，组长）

4. 多相微流技术可控合成纳米贵金属胶体，2021，王文雅（2019级，组长）、袁连洁（2018级）

主持项目:

1.    国家自然科学基金面上项目：Ag@CPPs（细胞穿膜肽）纳米簇的生理微环境稳定性、光致发光及辐照增敏效应研究，60万，项目号：51871055, 2019.1-2022.12

2.    国家自然科学基金青年科学基金项目：医用胶体银的可控连续合成及其在脑胶质瘤放疗中的特殊效应与敏化，25万，项目号：51201034, 2013.1-2015.12

3.    中央高校基本科研业务费-东南大学-南京医科大学合作项目：Ag@CPPs（细胞穿膜肽）纳米胶囊靶向脑胶质瘤放射增敏研究，6万，项目号：2242017K3DN13, 2017.7-2020.6

4.    中央高校基本科研业务费-基础扶持项目：合成银纳米颗粒中纳米棒、线等副产物的电场辅助去除研究，4万，项目号：2242018K40113, 2018.1-2018.12

5.    中央高校基本科研业务费-基础扶持项目：交变电场诱导胶体银形貌转变的研究，4万，项目号：2242017K40193, 2017.1-2017.12

6.    江苏省重点实验室自主研究课题项目：外场辅助聚乳酸骨支架体外矿化研究，10万，2018.11~2020.10

7.    东南大学新进教师科研启动项目：基于微流控技术宏量合成纳米银研究，10万，2019.1~2019.12

8.    人力资源和社会保障部2013年度中国博士后国际交流计划派出项目，30万，2014.5-2016.4

9.    江苏省博士后科研资助计划项目：基于电化学方法连续可控制备高纯度胶体银溶液，2万，项目号：1101008C, 2011.11- 2012.10

10.  2005年江苏省研究生创新计划项目：天然聚合物仿生矿化制备骨替换材料，1.8万，2005-2008

参与项目:

1.    国家自然科学基金面上项目：双靶点靶向载药银纳米复合物光热-化疗联合治疗乳腺癌的实验研究，50万，项目号：81771980，2018.1-2021.12，参与东南大学医学院合作

2.    国家自然科学基金面上项目：新型靶向探针GMT8-Ag@Au的构建及其在脑胶质瘤CT成像和辐射增敏一体化中的实验研究，67.2万，项目号：81571805, 2016.1-2019.12，参与东南大学医学院合作

3.    国家自然科学基金面上项目：纳米银体内外动力学和生物毒物动力学模型（PBTK）研究，68.4万，项目号：81573186, 2016.1-2019.12，参与东南大学公共卫生学院合作

4.    国家自然科学基金面上项目：新型靶向纳米药物Angio-Ag-NRPMAb的制备及其抑制胶质瘤的机制研究，72万，项目号：81471780, 2015.1-2018.12，参与东南大学附属中大医院合作

5.    国家自然科学基金青年科学基金项目：常用金属纳米材料的毒性效应及定量构效关系（QSAR）研究，23万，项目号：81302461, 2014.1-2016.12，参与东南大学公共卫生学院合作

6.    国家自然科学基金海外及港澳学者合作研究基金项目：基于氮化铝镓/氮化镓场效应的细胞电生理传感研究，20万，项目号：61328104，2014/01-2015/12

期刊论文：

1.    Linyuan Han, Zhenwei Zhang, Jianwei Dai, Xuan Li, Jing Bai, Zhihai Huang, Chao Guo, Feng Xue, Chenglin Chu. The influence of alternating cyclic dynamic loads with different low frequencies on the bio-corrosion behaviors of AZ31B magnesium alloy in vitro[J]. Bioactive Materials, 2022, 7: 263-274

2.    Jinglong Feng, Zhihai Huang, Yinsheng Dong. Preparation of ice microspheres and their application in the preparation of porous poly(L-lactic acid) (PLLA) scaffolds[J]. Journal of Materials Science, 2019, 54(4): 3661-3670

3.    Jinglong Feng, Zhihai Huang, Yinsheng Dong. Effect of mixed solvents on the thermal properties of poly(L-lactic acid) (PLLA) solution and micromorphology of porous PLLA scaffolds[J]. Materials Research Express, 2019, 015314

4.    Xulong An, Hui Zhao, Ting Dai, Hongguang Yu, Zhihai Huang, Chao Guo, Paul K. Chu, Chenglin Chu. Effects of heat treatment on the microstructure and properties of cold-forged CoNiFe medium entropy alloy[J]. Intermetallics, 2019, 110: 106477

5.    Xulong An, Hui Zhao, Chenglin Chu, Ting Dai, Tao Lu, Zhihai Huang, Chao Guo, Paul K Chu. Hall-Petch relationship and corrosion behavior of cold-rolled CoNiFe medium entropy alloy[J]. Journal of Alloys and Compounds, 2019, 807: 151698

6.    Jun Lin, Yiming Liu, Hao Wu, Zhihai Huang, Jingfan Ma, Chang Guo, Feng Gao, Peipei Jin, Pengfei Wei, Yunjiao Zhang, Liu Liu, Rui Zhang, Longxin Qiu, Ning Gu, Longping Wen. Key Role of TFEB Nucleus Translocation for Silver Nanoparticle-Induced Cytoprotective Autophagy[J]. Small, 2018, 13(14): 1703711(1-10)

7.    Lingying Zhu, Dawei Guo (co-first author), Lili Sun, Zhihai Huang, Xiuyan Zhang, Wenjuan Ma, Jie Wu, Lu Xiao, Yun Zhao, Ning Gu. Activation of autophagy by elevated reactive oxygen species rather than released silver ions promotes cytotoxicity of polyvinylpyrrolidone-coated silver nanoparticles in hematopoietic cells[J]. Nanoscale, 2017, 9(17): 5489-5498

8.    Qi Ding, Dongfang Liu, Dawei Guo, Fang Yang, Xingyun Pang, Renchao Che, Naizhen Zhou, Jun Xie, Jianfei Sun, Zhihai Huang, Ning Gu. Shape-controlled fabrication of magnetite silver hybrid nanoparticles with high performance magnetic hyperthermia[J]. Biomaterials, 2017, 124: 35-46

9.    Hao Wu, Jun Lin, Peidang Liu, Zhihai Huang, Peng Zhao, Haizhen Jin, Jun Ma, Longping Wen, Ning Gu. Reactive oxygen species acts as executor in radiation enhancement and autophagy inducing by AgNPs[J]. Biomaterials, 2016, 101: 1-9

10.  Zhihai Huang, Hao Jiang, Peidang Liu, Jianfei Sun, Dawei Guo, Jieling Shan, Ning Gu. Continuous synthesis of size-tunable silver nanoparticles by green electrolysis method and multi-electrode design for high yield[J]. Journal of Materials Chemistry A, 2015, 3: 1925-1929

11.  Hao Wu, Jun Lin, Peidang Liu, Zhihai Huang, Peng Zhao, Haizhen Jin, Cailian Wang, Longping Wen, Ning Gu. Is the autophagy a friend or foe in the silver nanoparticles associated radiotherapy for glioma?[J]. Biomaterials, 2015, 62: 47-57

12. Dawei Guo, Dandan Dou, Lin Ge, Zhihai Huang, Liping Wang, Ning Gu. A caffeic acid mediated facile synthesis of silver nanoparticles with powerful anti-cancer activity[J]. Colloids and Surfaces B: Biointerfaces, 2015, 134: 229-234

13.  Dawei Guo, Junren Zhang,Zhihai Huang, Shanxiang Jiang, Ning Gu. Colloidal silver nanoparticles improves anti-leukemic drug efficacy via amplification of oxidative stress[J]. Colloids and Surfaces B: Biointerfaces, 2015, 126: 198-203

14.  Jun Lin, Zhihai Huang, Hao Wu, Wei Zhou, Peipei Jin, Pengfei Wei, Yunjiao Zhang, Fang Zheng, Jiqian Zhang, Jing Xu, Yi Hu, Yanhong Wang, Yajuan Li, Ning Gu, Longping Wen. Inhibition of autophagy enhances the anticancer activity of silver nanoparticles[J]. Autophagy, 2014, 10(11): 2006-2020

15. Dawei Guo, Yun Zhao, Yu Zhang, Qing Wang, Zhihai Huang, Qi Ding, Zhirui Guo, Xuefeng Zhou, Lingying Zhu, Ning Gu, The Cellular Uptake and Cytotoxic Effect of silver Nanoparticles on Chronic Myeloid Leukemia Cells[J]. Journal of Biomedical Nanotechnology, 2014, 10(4): 669-678

16.  Peidang Liu, Zhihai Huang (co-first author), Zhongwen Chen, Ruizhi Xu, Hao Wu, Fengchao Zang, Cailian Wang, Ning Gu. Silver nanoparticles: a novel radiation sensitizer for glioma?[J]. Nanoscale, 2013, 5: 11829-11836

17.  Zhihai Huang, Qing Wang, Zhirui Guo, Lina Xu, Dongfang Liu, Qi Ding, Ning Gu. Rapid synthesis of high-stable silver nanoparticles by electrochemical method[J]. Nanoscience and Nanotechnology Letters, 2013, 5(2): 232-236

18.  Dawei Guo, Lingying Zhu, Zhihai Huang, Haixia Zhou, Yue Ge, Wenjuan Ma, Jie Wu, Xiuyan Zhang, Xuefeng Zhou, Yu Zhang, Yun Zhao, Ning Gu. Anti-leukemia activity of PVP-coated silver nanoparticles via generation of reactive oxygen species and release of silver ions[J]. Biomaterials, 2013, 34(32): 7884-7894

19.  Peidang Liu, Zhihai Huang, Ning Gu. Exposure to silver nanoparticles does not affect cognitive outcome or hippocampal neurogenesis in adult mice[J]. Ecotoxicology and Environmental Safety, 2013, 87: 124-130

20.  Jun Dou, Xiangfeng He (co-first author), Yunjing Liu (co-first author), Zhihai Huang, Cuiping Yang, Fangfang Shi, Dengyu Chen, Ning Gu. Targeted therapeutic effect of anti-ABCG2 antibody combined with nano silver and vincristine on mouse myeloma cancer stem cells[J]. Journal of Nanoparticle Research, 2013, 15: 2127-2141

21.  Dawei Guo, Xiuyan Zhang (co-first author), Zhihai Huang, Xuefeng Zhou, Lingying Zhu, Yun Zhao, Ning Gu. Comparison of cellular responses across multiple passage numbers in Ba/F3-BCR-ABL cells induced by silver nanoparticles[J]. Science China (Life Sciences), 2012, 55(10), 898-905

22.  Zhihai Huang, Xiaoli Jiang, Dawei Guo, Ning Gu. Controllable synthesis and biomedical applications of silver nanomaterials[J]. Journal of Nanoscience and Nanotechnology, 2011, 11: 9395-9408

23.  Zhihai Huang, Yinsheng Dong, Pinghua Lin. Depositing an Apatite Coating in/on Massive Chitosan Porous Scaffolds by an Alternate Soaking Method[J]. Acta Physico-Chimica Sinica, 2009, 25(7): 1285-1289 (in Chinese)

24.  Zhihai Huang，Jihong Li, Pinghua Lin, Yinsheng Dong, Chao Guo, Xiaobo Sheng, Chenglin Chu. Electrochemistry assisted depositing hydroxyapatite coating in chitosan porous scaffold[J]. Acta Polymerica Sinica, 2009, (3): 273-277 (in Chinese)

25.  Zhihai Huang, Yinsheng Dong, Chenglin Chu, Pinghua Lin. Electrochemistry assisted reacting deposition of hydroxyapatite in porous chitosan scaffolds[J]. Materials Letters, 2008, 62(19): 3376-3378

26.  Zhihai Huang, Lei Yang, Yinsheng Dong, Pinghua Lin. Fabrication of chitosan sponge as dressings by phase separation-extraction method[J]. The Chinese Journal of Nonferrous Metals, 2007, 17(s1): 268-274 (in Chinese)

27.  Zhihai Huang, Yinsheng Dong, Chao Guo, Pinghua Lin. Study of freeze-drying process of natural polymer porous scaffolds[J]. Journal ofChina Biotechnology, 2004, 24(11): 76-79 (in Chinese)

28.  Zhihai Huang, Yinsheng Dong, Chao Guo, Pinghua Lin. Study on fabrication of porous chitosan-collagen scaffolds[J]. Chemical Industry Times, 2004, 18(10): 36-39 (in Chinese)

会议论文:

1.    Jijinhua Liu, Pingping Zhou, Zhihai Huang, Chenglin Chu. Improving thermal stability of fluorescent silver nanoclusters with glutathione ligand. 2021 Chinese Biomaterials Congress, October 2021, Shanghai, China

2.    Yingshi Liu, Xuna Tang, Pingping Zhou, Jijinhua Liu, Zhihai Huang, Chenglin Chu. Preparation of polyurethane antibacterial catheters loaded with silver nanoparticles by modification of polydopamine. 2021 Chinese Biomaterials Congress, October 2021, Shanghai, China

3.    Ziyuan Fang, Shanyun Sun, Jijinhua Liu, Pingping Zhou, Zhihai Huang, Yinsheng Dong, Chenglin Chu. Mineralized deposition of calcium carbonate based on millimeter-scale chitosan porous microspheres by electric field assistance. The 15th Bioinorganic Chemistry Conference of Chinese Chemical Society, October 2021, Taiyuan, China

4.    Zhihai Huang, Jinglong Feng, Shanyun Sun, Chao Guo, Yinsheng Dong. Development of ice-based porogens for tissue engineering scaffolds. 2019 Chinese Biomaterials Congress and International Symposium on Advanced Biomaterials, August 2019. Dalian, China

5.    Zhihai Huang, Jiayi Li, Pingping Zhou, Weizhao Wang, Dijie Huang, Binxu Wu. The synthesis of silver nanoparticles based on continuous microflow or microdroplet methods. Chinese Materials Conference 2019, July 2019. Chengdu, China

6.    Zhihai Huang， Zhirui Guo，Ning Gu. Removal of by-products from synthesized silver nanoparticles assisted by alternating electric field. The conference of Chinese Society for Biomaterials in 2017, Oct. 2017. Nanchang, China

7.    Jinglong Feng, Zhihai Huang*, Yinsheng Dong*. Preparation of micro-nano porous structure PLA bone tissue engineering scaffold. The conference of Chinese Society for Biomaterials in 2017, Oct. 2017. Nanchang, China

8.    Hao Wu, Jun Lin, Peidang Liu, Zhihai Huang, Cailian Wang, Longping Wen, Ning Gu. Protective Autophagy in AgNPs Associated Radiotherapy for Glioma. 2015 International Conference on Biomedical Application of Nanomaterials, Dec. 2015, Hong Kong, China

9.    Hao Wu, Jun Lin, Peidang Liu, Zhihai Huang, Peng Zhao, Haizhen Jin, Cailian Wang, Longping Wen, Ning Gu. Protective Autophagy in the silver Nanoparticles Associated Radiotherapy for Glioma. 2015 International Workshop On Detection and Analysis of Single Blood Cancer Cells, Nov. 2015, Nanjing, China

10.  Zhihai Huang, Ning Gu. The synthesis of water-soluble fluorescent silver nanoclusters by electrochemical method. The conference of Chinese Society for Biomaterials in 2013, Dec. 2013. Shenzhen, China

11.  Zhihai Huang, Yinsheng Dong, Chenglin Chu, Pinghua Lin, Ning Gu. Induced bone-like apatite deposit on chitosan composite scaffolds in vitro. The conference of Chinese Society for Biomaterials in 2013, Dec. 2013. Shenzhen, China

12.  Zhihai Huang, Dawei Guo, Ning Gu. Continuous flow synthesis of different sized colloidal silver nanoparticles by electrochemical method. Sino-Singapore Symposium on Functional Nanomaterials and Bioelectronics, Nov. 2011, Nanjing, China

13.  Zhihai Huang, Yinsheng Dong, Pinghua Lin. Phase separation-extraction method fabricates 3D chitosan tissue engineering scaffolds. The 5th International Conference on Advanced Materials and Processing, Sep. 2008, Harbin, China

14.  Zhihai Huang, Lei Yang, Yinsheng Dong, Pinghua Lin. Fabrication of chitosan sponge as dressings by phase separation-extraction method. Materials Science and Engineering Doctoral Forum of China, Oct. 2007, Changsha, China

15.  Zhihai huang，Yinsheng Dong，Pinghua Lin. The preparation and XRD analysis of biomimetic bone composite materials. The First Annual Meeting for Young Scientists of Jiangsu Province, Jun. 2006, Nanjing, China

授权专利:

1.    董寅生，肖夫兰，耿银雪，郭超，黄志海，储成林，盛晓波.用于磷酸钙骨水泥的含钙化合物添加剂的合成方法[P].中国发明专利，ZL201710256324.5. 2019-9-10

2.    董寅生，肖夫兰，耿银雪，郭超，黄志海，储成林，盛晓波.一种用作生物材料的钙盐混合物制备方法[P].中国发明专利，ZL201710256366.9. 2019-5-31

3.    董寅生，黄志海，盛晓波，储成林，郭超，林萍华，浦跃朴.胶原-β-磷酸三钙复合球形颗粒的制备方法[P].中国发明专利，ZL200810235061.0. 2012-10-24

4.    董寅生，黄志海，盛晓波，储成林，郭超，林萍华，浦跃朴.胶原-羟基磷灰石复合球形颗粒的制备方法 [P].中国发明专利，ZL200810235064.4；2013-4-3

5.    董寅生，林萍华，浦跃朴，郭超，黄志海，黄拙.对流式真空冷冻干燥装置 [P].中国发明专利，ZL03152861.9.2005-9-14

6.    董寅生，林萍华，浦跃朴，郭超，黄志海，黄拙.聚合物多孔材料的冷冻干燥装置[P].中国发明专利，ZL03152860.0. 2005-11-23

（更新时间：2021年10月）