院庆30周年系列学术报告通知——Research and Development of Novel Biodegradable Magnesium Alloys for Medical Applications

Guangyin Yuan, Ph.D, Professor

National Engineering Research Center of Light Alloy Net Forming,

Shanghai Jiao Tong University, Shanghai 200240, China

Tel: 86-21-34203051, Fax: 86-21-34202794, E-mail: gyyuan@sjtu.edu.cn

报告时间：2014年9月25日周四上午10:00

报告地点：九龙湖校区材料楼B楼432会议室

Being biocompatible and biodegradable, magnesium alloys are considered as the promising biomedical degradable implant materials, such as for cardiovascular stents, bone fixtures, plates and screws, which would avoid secondary surgeries to remove after the tissue healed. The challenges for the current commercial Mg alloys as biomaterials are the serious localized corrosion behavior, poor bio-safety and low mechanical properties. Requirements for biodegradable implants are good biocompatibility, controlled biodegradability and sustainable mechanical properties. To solve these issues, scientific composition design and microstructure regulation as well as fabrication process with high purity should be systematically considered and adopted. Aided with the first principle calculation and molecular dynamic (MD) simulation, novel biodegradable Mg alloys JDBM series have been designed and developed in recent years. The patented JDBM series alloys exhibit the favorable uniform corrosion degradation behavior and degradation controllability, i.e., JDBM-1 exhibits high strength and medium ductility which will be used as Bone implants, and JDBM-2 exhibits high ductility and medium strength which will be used as cardiovascular stents. In this talk, the alloy design strategy, microstructure, mechanical properties and degradation behavior will be introduced. The in vitro and in vivo experimental results of JDBM series alloys as bone implants and cardiovascular stents will be evaluated, respectively. The primary results show that the JDBM series alloys have a promising clinical application prospect.

袁广银 ，男，1970年生，上海交通大学材料科学与工程学院，教授，博士生导师。入选2007年教育部“新世纪优秀人才支持计划”。2000年3月毕业于东南大学材料科学与工程学院，获博士学位。现任上海交通大学轻合金精密成型国家工程研究中心副主任，上海交大材料学院生物医用材料研究所副所长，中国材料研究学会青年委员会常务理事，中国医用镁合金产业技术创新战略联盟副理事长。长期从事高性能镁合金强韧化设计和微观组织与性能关系研究、可降解医用镁合金临床应用研究。所研发的具有自主知识产权的可降解医用镁合金材料已获得国外著名医疗器械公司的认可和资助。近年来在可降解医用镁合金材料领域作为负责人先后承担了上海市基础研究重大项目、上海市产学研医合作研究项目、科技部“十二五”科技支撑项目以及科技部863项目等纵向课题和两项企业横向合作课题。已发表镁合金材料领域SCI研究论文60余篇，被他人引用600余篇次。多次应邀参加国际学术会议作大会发言，申请镁合金材料方面发明专利16项，包括生物医用镁合金相关专利8项（含1项美国专利）。出版了《镁合金科学与技术》专著一部（科学出版社，2007.1）。荣获上海市科技进步一等奖、上海市发明创造专利奖三等奖，获首届上海交通大学“晨星青年学者奖励计划”SMC优秀青年教师奖。